Cyclooxygenase Inhibitors

Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.

Also Known As:

Cyclo-Oxygenase Inhibitors; Inhibitors, Cyclo-Oxygenase; Inhibitors, Cyclooxygenase; Inhibitors, Prostaglandin Synthase; Inhibitors, Prostaglandin-Endoperoxide Synthase; Antagonist, Prostaglandin Synthesis; Antagonists, Prostaglandin Synthesis; Cyclo Oxygenase Inhibitor; Cyclo Oxygenase Inhibitors; Inhibitor, Cyclo-Oxygenase; Inhibitor, Cyclooxygenase; Inhibitor, Prostaglandin Synthase; Inhibitors, Cyclo Oxygenase; Inhibitors, Prostaglandin Endoperoxide Synthase; Synthase Inhibitor, Prostaglandin; Synthesis Antagonist, Prostaglandin; Cyclo-Oxygenase Inhibitor; Cyclooxygenase Inhibitor; Prostaglandin Endoperoxide Synthase Inhibitor; Prostaglandin Endoperoxide Synthase Inhibitors; Prostaglandin Synthase Inhibitor; Prostaglandin Synthase Inhibitors; Prostaglandin Synthesis Antagonist; Prostaglandin Synthesis Antagonists

Chemical Actions and Uses
- Pharmacologic Actions: 164
  - Therapeutic Uses: 49043
    - Antirheumatic Agents: 5363
      - Non-Steroidal Anti-Inflammatory Agents: 17077
        Cyclooxygenase Inhibitors: 1026
    - Anti-Inflammatory Agents: 4344
      - Non-Steroidal Anti-Inflammatory Agents: 17077
        Cyclooxygenase Inhibitors: 1026
  - Molecular Mechanisms of Pharmacological Action: 26
    - Enzyme Inhibitors: 1680
      - Cyclooxygenase Inhibitors: 1026
  - Physiological Effects of Drugs: 1
    - Peripheral Nervous System Agents: 5
      - Sensory System Agents
        Analgesics: 41572
        Non-Narcotic Analgesics: 887
        Non-Steroidal Anti-Inflammatory Agents: 17077
        Cyclooxygenase Inhibitors: 1026

F Kastelein Selected Research

F Kastelein Research Topics

Disease

Drug/Important Bio-Agent (IBA)